The Madrid headquarters of Casa Árabe is located in a Neo-Mudejar building constructed in 1886 on Calle Alcalá, alongside the northern entrance to the Retiro Park, which houses the Aguirre Schools at the end of the 19th century.  

The building was a project by the architect, Emilio Rodríguez Ayuso, who designed it as a two-storey building capable of housing highly innovative educational spaces for that period, such as a gymnasium, library, school museum, playground, music hall and even a meteorological observatory in the tower.  

Casa Árabe has a headquarters in Cordoba and in Madrid and it is supported by diverse public institutions such as the Ministry for Foreign Affairs and the Spanish Agency for International Cooperation, the regional governments of Madrid and Andalusia, and the Councils of Madrid and Cordoba.

Its services include a media library and the Balqis bookshop, specialised in the Arab culture.